Langerhans cellhistiocytosis is a rare disease with a wide spectrum of clinical presentations.It is a multisystemic disease with organ system involvement ranging fromsimple—where it involves only one organ—to widespread progressive disease.Although it can affect any age group, the peak incidence is between 1 and 3years of age.
A 27-year-old manpresented with an 8 months’ history of back pain radiating to his leg. Imagingrevealed an expansile lytic lesion in the body of the first sacral vertebra(S1) (Figs. 1-7). CT-guided biopsy was subsequently performed (Fig. 8), andhistology confirmed the lesion to be Langerhans cell histiocytosis.
Figure 1. Plain dorsal and lumbar spine x- rayof 27-year-old male patient 8 months before CT-guided biopsy. It is not easy tofind the expansile lytic sacral lesion on this image
Figure 2. PlainAxial FSE T1W image of first sacral vertebra shows slightly increased signal inthe sacral lesion (arrow).
Figure 3.Sagittal FSE T1W image of the first sacralvertebra shows slightly increased signal in the lesion (arrow).
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||参考文献：http://radiology.casereports.net/index.php/rcr/article/view/941/1231;Hatem MA,Langerhans cell histiocytosis of the sacrum. Radiology CaseReports. (Online)2014;9(3);941